Which PGT test is designed to detect chromosomal structural rearrangements?

Which PGT test is designed to detect chromosomal structural rearrangements?

• A. PGT-A
• B. PGT-M
• C. PGT-SR
• D. PGT-D

Answer: (C)

Detecting chromosomal structural rearrangements is the goal of PGT-SR. Structural rearrangements—such as balanced translocations, inversions, or other rearrangements—alter the way chromosome segments are organized rather than simply changing the number of chromosomes. When a parent carries a balanced rearrangement, their embryos can inherit unbalanced versions, leading to miscarriage or a child with congenital issues. PGT-SR focuses on identifying the exact chromosome structure in embryos, so you can select those with a normal or balanced arrangement for transfer. In contrast, PGT-A looks for whole-chromosome copy-number changes (aneuploidy) across the genome, not the arrangement of chromosome segments; PGT-M targets specific single-gene disorders; PGT-D covers other indications that don’t fit the first three categories.

Detecting chromosomal structural rearrangements is the goal of PGT-SR. Structural rearrangements—such as balanced translocations, inversions, or other rearrangements—alter the way chromosome segments are organized rather than simply changing the number of chromosomes. When a parent carries a balanced rearrangement, their embryos can inherit unbalanced versions, leading to miscarriage or a child with congenital issues. PGT-SR focuses on identifying the exact chromosome structure in embryos, so you can select those with a normal or balanced arrangement for transfer.

In contrast, PGT-A looks for whole-chromosome copy-number changes (aneuploidy) across the genome, not the arrangement of chromosome segments; PGT-M targets specific single-gene disorders; PGT-D covers other indications that don’t fit the first three categories.